Ozone therapy as an adjuvant treatment for diabetic foot ulcers: a case series from Asunción, Paraguay

Abstract

Introduction: Diabetes mellitus is a major public health concern due to its chronic complications, including diabetic foot ulcers. Methods: This descriptive retrospective observational case series aimed to explore the potential effects of ozone therapy as an adjuvant treatment for wound healing in diabetic patients at the Centro del Pie in Asunción during 2023. A purposive sample of seven patients was analyzed through medical records using the Texas and RESVECH 2.0 scales. Results: Results showed complete healing in five patients, particularly those with less severe lesions (Texas II/B) and higher ozone session counts. Although a favorable clinical trend was observed, the small sample size and non-experimental design limit causal inference. Conclusions: Further controlled studies with greater methodological rigor are required to confirm the efficacy of ozone therapy and support its broader clinical adoption.